Interesting preliminary results have already been obtained with theophylline administered by 2ml osmotic pumps. Following oral administration of mesalamine mg three times daily , the elimination half-life of the drug was found to be 1. If the substance taken is too acidic or caustic, it can burn the lining causing irreparable damage. In a pediatric critical care environment, rectal administration of medication may be most beneficial when intravenous access issues are present, either because of an inability to maintain or achieve intravenous access or in situations when placement of an intravenous line is otherwise not necessary. Following the rectal administration of mesalamine suspension in adults, the drug has been found to distribute from the rectum into the colon, reaching the splenic flexure, and possibly the ascending colon. Topical administration is a local effect where the drug is applied directly to the area that it is needed. Unwanted effects such as histamine release during intravenous administration of some agents primarily pethidine can make the intravenous route unsuitable.
5.2 Speed of drug effect
While prescribed medications taken rectally involve proper lubrication and a sterile syringe or applicator, those afflicted with substance abuse may not bother with these steps, causing harm to the rectal tissues and membranes. Intervention Do I have a Problem? Add to My Bibliography. There have, however, been cases of people dying from swallowing cocaine , showing that there are still some dangers present with this particular route of administration. The nurse should wash his or her hands and put on gloves.
How medicaments are absorbed through rectum? – BlissGVS
Increased incidence of recurrence associated with independent risk factors: If an inadequate dose has been taken, it can be corrected with ease by simply adding to what has been consumed. Reducing drug-related harm Rectal administration may potentially be an important route for peptide administration, although among available options it is poorly accepted by patients. Mail will not be published required.
It is not safe in the hands of those who have not got the training to do so. When the medication is given, there can be no recall. However, the rectal absorption of peptide and protein drugs is still poor as compared with intravenous administration. References are available online at http: Rectal solutions are employed as enemas or cleansing solutions. For our intents and purposes you should understand that polar substances will not dissolve into a non-polar solvent. Powdered drugs, or crushed up pills and crystal rocks can be dabbed or rubbed into the lining of your rectum with your finger.